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After decades of research and use in the medical field, polynucleotides are a fairly new, sophisticated development in aesthetics: these ‘biostimulators’ work at a cellular level, triggering skin to regenerate itself. As polynucleotides initiate your body’s natural fibroblast production, this results in increased collagen and a thicker, healthier epidermis. As opposed to temporarily adding volume, they are a form of skin revitalisation, treating overall skin quality, scarring and also challenging areas to treat, such as the under eye area.


Using filtered, ultra-purified and sterilised natural DNA fractions, these injectable serums deliver a raft of benefits for skin – firstly, working as a wound healing agent (on scar tissue and skin imperfections) then using their antioxidant properties to boost cell renewal, reduce inflammation and restore youthful volume and hydration. This type of ‘regenerative medicine’ prompts skin to perform better over time, using its own, natural process, so is a welcome, longer-term option for smoother, brighter, healthier skin.

Get in touch here to book a consultation or speak to a member of our specialist team on +44 (0)20 7486 3849.

Benefits of Polynucleotides

Tailored results

Improves skin quality

Natural, ongoing results

More youthful appearance

Safe & effective

At a glance

Numbing cream applied

Anaesthetic required

45-60 minutes

Appointment time



Up to 48 hours


6 to 9 months

Frequency of treatment

Conditions Treated

Acne & scarring

General skin health

Lines & wrinkles

Rosacea & redness

Under eye


“From the first phone call to reception through to time spent with the doctors, Waterhouse Young Clinic makes prospective patients feel well looked after and comfortable as they consider potential ...

JE, Lawyer


“Who knew that a neck treatment could be so relaxing and I never imagined my skin would ever feel this smooth from the wonderful Allskin Med products. I was sceptical ...

Gaby Roslin


“I’ve trusted the doctors at Waterhouse Young clinic for 10 years and – if I say so myself – I’m pretty pleased with the quality of my skin and how ...

Alice B-B, Spa Editor, Times LUXX


When my skin feels tired Waterhouse Young HydraFacials are my go-to – my skin feels fresh, hydrated, and firmer. I love them especially before an event for an extra glow.

Suki Waterhouse, Model & Actress


I visited Waterhouse Young for my pre-wedding skin prep and wasn’t disappointed! My skin has never been in better condition, and it was literally glowing on the day thanks to ...

Gabriella Maubec


Love visiting this clinic! Leanne and Dr Paris are so friendly and welcoming you feel like no time has passed since the last visit. All my treatments look so natural ...

Alexandra Simpson


Everyone is so lovely and knowledgable here. My skin has never felt so good.

Dani Tucker


Highly professional and friendly staff, made me feel very welcome on my first visit. Had the hydrafacial and my skin has never felt better! Can’t recommend Waterhouse Young enough.

Natasha Patterson


So delighted with the results. WY’s lovely team recommended the Seqex bed for my inflammartory condition and, having had the issue for 5 years , have to say I was ...

Melanie Parkfield


I was recommended the clinic by a friend and have been for a series of their HydraFacial ahead of my wedding. I cannot say enough good things, the team are ...

Sarah Powell


Awesome clinic, Anna and her team are clearly really passionate about what the do, not only do they help you look great but they’re really care about your well being, ...

Alan S Adams

Polynucleotide treatment guide & FAQs

Before we carry out any treatment, we will ask you to book an initial consultation with one of our aesthetic doctors. Here we will take a full medical history and, if required, carry out a Visia computerised skin analysis that allows us to examine magnified 3D images of your face.

We will also carry out a visual assessment of your skin and talk to you about your needs, hopes and expectations. Having gathered all this valuable information, we will then have a better understanding of which treatment you need to achieve the best outcome.

It may be that you come to us with a specific treatment in mind however, if on assessment, we feel an alternative might be more appropriate then we’ll let you know. Whatever the case, we will very much consider your individual needs and give you an honest assessment, including realistic expectations of the outcomes of your treatment.

Polynucleotide skin treatments are a super effective form of skin booster, known as bio- or skin revitalisation treatments, made from filtered, ultra-purified and sterilised natural DNA fractions in the form of an injectable serum. They differ from other skin boosters in that they’re not made from hyaluronic acid and they initiate your body’s natural fibroblast production which in turn produces collagen and elastin, the skin’s natural proteins. Polynucleotides were developed after over 40 years of scientific research and development, have been used in the medical field for over 35 years and are not associated with adverse reactions.

One of the unique properties of hyaluronic acid is that it can hold up to 1000 times its body weight of water. Whilst some cosmeceutical products and treatments help, the most popular and effective way to restore lost HA is by using injectable treatments.

At Waterhouse Young, we use Plenhyage and Mastelli polynucleotide products.

Unlike dermal fillers and hyaluronic-acid-based skin boosters which temporarily plump skin, polynucleotides are powerful wound healing polymers that kick start your body’s own regeneration process, helping to repair tissue by restoring cell damage and deeply nourishing skin cells.

Polynucleotides are used to improve skin elasticity, thickness, hydration, texture and overall skin health. They are commonly used to treat sun damaged skin / photoaging, hyperpigmentation, rosacea, stretch marks and acne scarring, as well as to counteract dark circles under the eyes and to strengthen the thin skin around lips – notoriously difficult areas to treat. Areas we can treat include the face, scalp, neck, decolletage, upper arms and hands, as well as other areas – for example, where you have scarring from surgery.

They are also an excellent alternative for patients who aren’t suitable for tear trough filler or who react to hyaluronic-acid-based products

Treatment will take from 45 to 60 minutes, including numbing cream.

You may notice small bumps at the injection sites while the product is absorbed – this is normal and subsides within a day or two. If you are having your neck treated, the bumps may last a little longer as skin there is thinner. You may also experience mild redness, tenderness or itching temporarily. With any injection, there is a small risk of post-treatment bruising or slight swelling at injection points however, as we inject so superficially, this is minimal.

As a topical anaesthetic cream is applied, you will barely feel the injections being administered.

Results will be visible from around 6 to 12 weeks after treatment. This is because these products work on a cellular level over time, rather than acting like dermal fillers which replace lost volume in the short term.

You will need three treatments, spaced 2 to 4 weeks apart. You may then choose to have single treatments in 6 to 9 months’ time to maintain results.

A single treatment costs £450 and a course of 3 treatments is £1250.

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Get in touch

We look forward to welcoming you to our London skin clinic in the heart of the Harley Street medical district.